Sodium-glucose co-transporter 2 (SGLT2) inhibitors include canagliflozin and dapagliflozin. They work by inhibiting the reabsorption of glucose in the kidneys, causing glucose to be excreted in the urine (glycosuria).1,3
Overall, success with inhaled insulins has been limited. This dosage form of insulin is not as effective as other treatments in helping patients to meet their blood sugar goal (A1C level less than 7 percent), and sales have been weak.
High blood sugar (hyperglycemia). Your blood sugar level can rise for many reasons, including eating too much, being sick or not taking enough glucose-lowering medication. Check your blood sugar level as directed by your doctor, and watch for signs and symptoms of high blood sugar — frequent urination, increased thirst, dry mouth, blurred vision, fatigue and nausea. If you have hyperglycemia, you’ll need to adjust your meal plan, medications or both.
If you smoke or use other types of tobacco, ask your doctor to help you quit. Smoking increases your risk of various diabetes complications. Talk to your doctor about ways to stop smoking or to stop using other types of tobacco.
Fig. 8.2 outlines these options, as well as recommendations for further intensification, if needed, to achieve glycemic goals. If a patient is still above the A1C target on premixed insulin twice daily, consider switching to premixed analog insulin three times daily (70/30 aspart mix, 75/25 or 50/50 lispro mix). In general, three times daily premixed analog insulins have been found to be noninferior to basal-bolus regimens with similar rates of hypoglycemia (62). If a patient is still above A1C target on basal insulin plus single injection of rapid-acting insulin before the largest meal, advance to a basal-bolus regimen with ≥2 injections of rapid-acting insulin before meals. Consider switching patients from one regimen to another (i.e., premixed analog insulin three times daily to basal-bolus regimen or vice-versa) if A1C targets are not being met and/or depending on other patient considerations (60,61). Metformin should be continued in patients on combination injectable insulin therapy, if not contraindicated and if tolerated, for further glycemic benefits.
As self-management of diabetes typically involves lifestyle modifications, adherence may pose a significant self-management burden on many individuals. For example, individuals with diabetes may find themselves faced with the need to self-monitor their blood glucose levels, adhere to healthier diets and maintain exercise regimens regularly in order to maintain metabolic control and reduce the risk of developing cardiovascular problems. Barriers to adherence have been associated with key psychological mechanisms: knowledge of self-management, beliefs about the efficacy of treatment and self-efficacy/perceived control. Such mechanisms are inter-related, as one’s thoughts (e.g. one’s perception of diabetes, or one’s appraisal of how helpful self-management is) is likely to relate to one’s emotions (e.g. motivation to change), which in turn, affects one’s self-efficacy (one’s confidence in their ability to engage in a behaviour to achieve a desired outcome).
Jump up ^ Malik VS, Popkin BM, Bray GA, Després JP, Hu FB (2010-03-23). “Sugar Sweetened Beverages, Obesity, Type 2 Diabetes and Cardiovascular Disease risk”. Circulation. 121 (11): 1356–64. doi:10.1161/CIRCULATIONAHA.109.876185. PMC 2862465 . PMID 20308626.
Type 2 diabetes is a completely preventable and reversible condition, and with diet and lifestyle changes, you can greatly reduce your chances of getting the disease or reverse the condition if you’ve already been diagnosed. If you are one of the millions of Americans struggling with diabetes symptoms, begin the steps to reverse diabetes naturally today. With my diabetic diet plan, suggested supplements and increased physical activity, you can quickly regain your health and reverse diabetes the natural way.
Jump up ^ Kubo, K; Aoki, H; Nanba, H (1994). “Anti-diabetic activity present in the fruit body of Grifola frondosa (Maitake). I”. Biological & Pharmaceutical Bulletin. 17 (8): 1106–10. doi:10.1248/bpb.17.1106. PMID 7820117.
In 2006 the FDA approved the first drug in this class called sitagliptin (Januvia). Sitagliptin can be used in combination with certain other medications, but its dose must be adjusted in patients with poor kidney function.
While some diabetics are tipped off to their condition by unintended weight loss, weight gain is nearly as common. Diabetes and thyroid disorders often go hand-in-hand, making diabetics more susceptible unwanted shifts on the scale. And when you’re ready to lose those pounds, ditch them with the 55 Best-Ever Ways to Boost Your Metabolism.
Another critic of the ADA program is futurologist and transhumanist Ray Kurzweil, who with Terry Grossman co-authored Fantastic Voyage: Live Long Enough to Live Forever (published 2004). They describe the ADA guidelines as “completely ineffective”. Their observations are that the condition, particularly in its early stages, can be controlled through a diet that sharply reduces carbohydrate consumption. Their guidelines for patients with type 2 diabetes is a diet that includes a reduction of carbohydrates to one sixth of total caloric intake and elimination of high glycemic load carbohydrates. As someone who was diagnosed with diabetes but who no longer has symptoms of the disease, Kurzweil is a firm advocate of this approach. However, Kurzweil’s prescription changed somewhat between his 1993 book The 10% Solution for a Healthy Life in which he recommended that only 10% of calories should come from fat and Fantastic Voyage which recommends 25%.